Imagine.
Incubate.
Ignite.
Advancing a New World of Clinical Research
i-Cubed™ is the center for clinical research innovation, powered by the unique expertise and resources of the Duke Clinical Research Institute. We support individuals, teams, and organizations in turning their ideas into tools, technologies, and processes that transform how clinical research is done — for the benefit of people everywhere.
If you have an idea or innovation that could solve a clinical research challenge, we want to work with you to:
Focus Areas
Research for all
Encouraging broad participation in research
Clinical research everywhere
Engaging communities beyond traditional research sites
Unleashing the power of all data
Moving beyond traditional data collection
New Tech Applications
Applying AI/ML and other new technologies to accelerate research
Simplifying the complex
Improving efficiency in processes to accelerate discoveries
A Culture of Innovation
Here at i-Cubed, we believe in finding positive approaches to problem-solving. We weave that commitment into everything we do in our work together and with our external partners. You’ll see that in practice when you collaborate with i-Cubed.
News
- Meet the Team: Matthew H. Maxwell, Entrepreneur in Residence May 11, 2026
What drew you to the EIR role at i-Cubed, and how does it align with the rest of your work? I’m drawn to upstream problems. Most of my work has been downstream, brought in when something’s already broken, when operations are fragmented and trials are underperforming. i-Cubed is different. It’s the moment before the pattern gets ...
- i-Cubed Innovation Spotlight Highlights Project Loom’s Vision for the Future of Clinical Trial Operations May 7, 2026
At its latest Innovation Spotlight event, i-Cubed brought together researchers, innovators, and clinical trial professionals for an immersive and engaging look at Project Loom, one of i-Cubed’s flagship R&D initiatives exploring how the integration of agentic AI is accelerating end-to-end clinical trial operations. The event featured a demonstration of Loom’s evolving platform capabilities and a broader discussion of how AI-driven ...
