Imagine.
Incubate.
Ignite.
Advancing a New World of Clinical Research
i-Cubed™ is the center for clinical research innovation, powered by the unique expertise and resources of the Duke Clinical Research Institute. We support individuals, teams, and organizations in turning their ideas into tools, technologies, and processes that transform how clinical research is done — for the benefit of people everywhere.
If you have an idea or innovation that could solve a clinical research challenge, we want to work with you to:
Focus Areas
Research for all
Encouraging broad participation in research
Clinical research everywhere
Engaging communities beyond traditional research sites
Unleashing the power of all data
Moving beyond traditional data collection
New Tech Applications
Applying AI/ML and other new technologies to accelerate research
Simplifying the complex
Improving efficiency in processes to accelerate discoveries
A Culture of Innovation
Here at i-Cubed, we believe in finding positive approaches to problem-solving. We weave that commitment into everything we do in our work together and with our external partners. You’ll see that in practice when you collaborate with i-Cubed.
News
- SPARK Grant Supports i-Cubed Vision for AI-Driven, End-to-End Clinical Trials March 25, 2026
What if agentic AI could provide end-to-end support for clinical trial execution? i-Cubed is one step further to realizing this dream so that clinical teams can apply their expertise where it matters most. A multi-disciplinary team, supported by i-Cubed and led by Principal Investigator Christoph Hornik, MD, PhD, has been awarded a Duke Science & Technology (DST) SPARK Seed Grant for their ...
- Meet the Team: Jeff Lee, Entrepreneur in Residence March 17, 2026
What drew you to the Entrepreneur in Residence (EIR) role at i-Cubed? I’ve collaborated with DCRI/CTTI in the past and have been consistently impressed with the caliber of the staff and leadership. Helping to guide and shape early-stage concepts allows me to leverage learnings from my prior startup experience and stay engaged with dynamic founders. How would ...
